Addison's disease and other conditions inducing hypocortisolism

EBM Guidelines
May 23, 2024 • Completely updated
Minna Soinio

Table of contents

Extract

  • The most common symptoms of insufficient levels of cortisol include weight loss, fatigue, nausea and hypotension. Skin hyperpigmentation may also be present. The disease may also present as an acute Addisonian crisis.
  • Patients receiving replacement therapy should increase the drug dose prophylactically in stressful situations.
  • The reference range and clinical decision-making thresholds of the cortisol concentration depend on the method used by the laboratory.
    • Check the relevant method comparison table in the laboratory’s handbook to find comparable cortisol concentrations.

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ACTH deficiency, ACTH test, Addison Disease, Addisonian crisis, Adrenal Insufficiency, Blood Pressure, Diarrhea, E27, E27.1, E27.2, E27.3#, E27.4, E35.1*, Endocrinology, Fludrocortisone, Fluid Therapy, Hydrocortisone, Hypocortisolism, Hypoglycemia, Hyponatremia, Hypopituitarism, Hypotension, Infection, Internal medicine, Mineralocorticoids, Surgical Procedures, Operative, Sweating, autoimmune adrenal insufficiency, electrolyte imbalance, long-time steroid treatment, salt hunger, substitution treatment, systemic glucocorticoid therapy